Pharmacology

Senescent cells are damaged or dysfunctional cells that acumulate in the body as we age, contributing to the aging process and age-related diseases. Senolytics are drugs that selectively eliminate senescent cells, with the aim of improving overall health and lifespan. Several senolytic drugs are currently being developed and tested in clinical trials.

Metformin is a drug commonly used to treat type 2 diabetes. It has also been shown to have anti-aging effects in animal studies, including extending lifespan and improving healthspan. Several clinical trials are currently investigating whether metformin can also have similar effects in humans.

Rapamycin is an immunosuppressant drug that has been shown to extend lifespan and improve healthspan in multiple animal species. It works by inhibiting the mTOR pathway, which is involved in cell growth and metabolism. Clinical trials are currently underway to investigate whether Rapamycin can have similar effects in humans.

NAD+ is a molecule that plays a key role in energy metabolism and cellular repair. Levels of NAD+ decline with age, and boosting NAD+ levels has been shown to have anti-aging effects in animal studies. Several NAD+ boosters are currently being developed and tested in clinical trials.

Caloric restriction is a well-established way to extend lifespan and improve healthspan in animal studies. Caloric restriction mimetics are drugs that mimic the effects of caloric restriction, with the aim of improving health and lifespan. Several drugs in this class are currently being developed and tested in clinical trials.

Vitamins, minerals, and other nutrients, are being investigated as a potential way to improve overall health and lifespan. Some supplements, such as resveratrol, have been shown to have anti-aging effects in animal studies, but more research is needed to determine whether these effects can be replicated in humans.